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手持一堆垃圾
2021-02-10
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Tianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%
手持一堆垃圾
2021-02-08
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00:54","market":"us","language":"zh","title":"Tianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%","url":"https://stock-news.laohu8.com/highlight/detail?id=1194244001","media":"老虎资讯综合","summary":"2月9日，临床阶段生物药企天演药业正式在纳斯达克挂牌上市，开盘涨8.95%，报20.7美元，市值8.73亿美元。\n\n天演药业发行价为19美元位于价格指导区间顶端，据悉本次发行735.4万份ADS，市值","content":"<p>On February 9, clinical-stage biopharmaceutical companies<a href=\"https://laohu8.com/S/ADAG\">Tianyan Pharmaceutical</a>Officially listed on Nasdaq, it opened up 8.95% at $20.7, with a market value of $873 million.</p><p><img src=\"https://static.tigerbbs.com/62e01ad7e249639d98c7aa993a51a167\" tg-width=\"1340\" tg-height=\"833\"></p><p>The issue price of Tianyan Pharmaceutical is US$19, which is at the top of the price guidance range. It is reported that 7.354 million ADS were issued this time, with a market value of US$801 million. Goldman Sachs, Morgan Stanley and Jeffery are the co-lead underwriters, and China Renaissance is the deputy underwriter.</p><p>According to media reports, Tianyan Pharmaceutical has a close relationship with CRO giant WuXi AppTec. WuXi AppTec is one of the investors of Tianyan Pharmaceutical, accounting for 10.8% of the shares. According to some analysts, the helper behind Tianyan Pharmaceutical's listing in the United States is WuXi AppTec.</p><p>According to official information, Tianyan Pharmaceuticals was founded in 2011 to transform the discovery and development of novel antibody-based cancer immunotherapies. In the years after its establishment, Tianyan Pharmaceutical independently developed dynamic precision antibody technology, established the world's largest diverse dynamic precision antibody library (DPL Platform), and the world's first high-throughput screening Platform that integrates accurate computational design and experimental structure and integrates yeast and phages.</p><p>Diversity dynamic precision antibody library is the core technology patent of Tianyan Pharmaceutical. The DPL platform is supported by a combination of computational physics technology with AI and big data. It can sample a potentially unlimited number of dynamic binding interface structures generated by massive antibody amino acid sequences, and produce first-come antibodies with both excellent biological functions and drug-ready properties, thus greatly improving the efficiency of antibody drug discovery.</p><p>Based on this own patent platform, Tianyan Pharmaceuticals has now developed three core products: ADG106, ADG116 and ADG126. Among them, ADG106, which is used to treat advanced solid tumors, non-Hodgkin's lymphoma or NHL, is undergoing clinical trials in China and the United States. It has been observed by the data to have good anti-tumor activity and tolerability, and is most expected to be commercialized.</p><p>Another product of Tianyan Pharmaceutical, ADG126, aims to address the toxicity and efficacy issues associated with MOA of existing approved CTLA-4 immuno-oncology therapies and expand the potential of CTLA-4 as a cancer therapeutic target. The product has now been approved by the FDA and will conduct phase I clinical trials in the United States this year.</p><p>As the founder of a rising star company in the field of biological antibodies, Luo Peizhi, the founder of Tianyan Pharmaceutical, is quite successful in the field of medical technology. Luo Peizhi graduated from Peking University and received his PhD from the University of Chicago. In 2000, Luo Peizhi founded a biomedical company named Abmaxis, which pioneered a three-dimensional experimental structure that does not rely on antibody antigens. It can design and optimize antibody calculation and screening methods, and provide technical services for the development of innovative drugs for many biological companies around the world. Because of its technological innovation, Abmaxis was acquired by Merck in 2006, and Luo Peizhi himself was hired by Merck as global biopharmaceutical R&D director.</p><p>Around 2011, under the influence of Li Ge, an alumnus and founder of WuXi AppTec, Luo Peizhi decided to return to China to start a business, and soon settled the company in Suzhou, not far from WuXi AppTec's headquarters. In 2014, Tianyan Pharmaceutical completed Series A financing, raising a total of US$8 million. The leading investment institutions include Yaokang Mingde Venture Capital Fund, Fidelity (Boston) Biotechnology Fund, etc. In 2016, WuXi AppTec continued to invest in Tianyan Pharmaceutical's Series B financing, helping Tianyan Pharmaceuticals raise another $28 million. In the following two years, Tianyan Pharmaceutical has successively completed round C and round D financing, with WuXi AppTec behind it.</p><p>Up to now, WuXi AppTec still holds 10.8% of Tianyan Pharmaceutical's shares as a wholly-owned subsidiary Wuxi Pharmaceutical Science and Technology Insurance Fund.</p><p>On the domestic CRO track, WuXi AppTec is undoubtedly the leader. Since 2012, WuXi AppTec has begun to invest in Biotech companies with potential, investing in shares in the early stage to obtain future profits. WuXi AppTec itself has certain clinical trial services and bioanalytical capabilities. In addition to funds, it can also support start-ups with these services. For example, Tianyan Pharmaceutical, in the two years from 2018 to 2020, purchased nearly $15 million in R&D services and quality testing services from WuXi AppTec.</p><p>According to the financial report, in 2018, 2019 and the first nine months ended September 30, 2020, as none of the products were listed, the company's revenue came entirely from the income of licensing patents to the pharmaceutical company Celgene, which was US$1.511 million, US$480,000 and US$310,000 respectively. During the same period, R&D expenditure increased year by year to $16.081 million, $16.212 million and $23.568 million respectively.</p><p>There are no listed drugs that can generate large revenues, and continuous R&D investment also caused Tianyan Pharmaceutical's net losses of US$14.303 million, US$16.678 million, and US$29.815 million in the same period, respectively. The basic and diluted losses per share attributable to common shareholders were $0.94, $1.10, and $1.89, respectively.</p><p>At present, Tianyan Pharmaceutical is also increasing investment in scientific research. The company introduced in the prospectus that Tianyan Pharmaceutical intends to use 95% of the net proceeds from this offering to advance the trial of drug candidates, of which about 26% will be used for the progress of the first and second phase trials of ADG106; 26% of the funds went to ADG126 and ADG116; 43% for the company's technology and platform development and the development of preclinical drug candidates; The remaining approximately 5% is for working capital and other general corporate purposes.</p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Tianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nTianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/102\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">老虎资讯综合 </p>\n<p class=\"h-time smaller\">2021-02-10 00:54</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>On February 9, clinical-stage biopharmaceutical companies<a href=\"https://laohu8.com/S/ADAG\">Tianyan Pharmaceutical</a>Officially listed on Nasdaq, it opened up 8.95% at $20.7, with a market value of $873 million.</p><p><img src=\"https://static.tigerbbs.com/62e01ad7e249639d98c7aa993a51a167\" tg-width=\"1340\" tg-height=\"833\"></p><p>The issue price of Tianyan Pharmaceutical is US$19, which is at the top of the price guidance range. It is reported that 7.354 million ADS were issued this time, with a market value of US$801 million. Goldman Sachs, Morgan Stanley and Jeffery are the co-lead underwriters, and China Renaissance is the deputy underwriter.</p><p>According to media reports, Tianyan Pharmaceutical has a close relationship with CRO giant WuXi AppTec. WuXi AppTec is one of the investors of Tianyan Pharmaceutical, accounting for 10.8% of the shares. According to some analysts, the helper behind Tianyan Pharmaceutical's listing in the United States is WuXi AppTec.</p><p>According to official information, Tianyan Pharmaceuticals was founded in 2011 to transform the discovery and development of novel antibody-based cancer immunotherapies. In the years after its establishment, Tianyan Pharmaceutical independently developed dynamic precision antibody technology, established the world's largest diverse dynamic precision antibody library (DPL Platform), and the world's first high-throughput screening Platform that integrates accurate computational design and experimental structure and integrates yeast and phages.</p><p>Diversity dynamic precision antibody library is the core technology patent of Tianyan Pharmaceutical. The DPL platform is supported by a combination of computational physics technology with AI and big data. It can sample a potentially unlimited number of dynamic binding interface structures generated by massive antibody amino acid sequences, and produce first-come antibodies with both excellent biological functions and drug-ready properties, thus greatly improving the efficiency of antibody drug discovery.</p><p>Based on this own patent platform, Tianyan Pharmaceuticals has now developed three core products: ADG106, ADG116 and ADG126. Among them, ADG106, which is used to treat advanced solid tumors, non-Hodgkin's lymphoma or NHL, is undergoing clinical trials in China and the United States. It has been observed by the data to have good anti-tumor activity and tolerability, and is most expected to be commercialized.</p><p>Another product of Tianyan Pharmaceutical, ADG126, aims to address the toxicity and efficacy issues associated with MOA of existing approved CTLA-4 immuno-oncology therapies and expand the potential of CTLA-4 as a cancer therapeutic target. The product has now been approved by the FDA and will conduct phase I clinical trials in the United States this year.</p><p>As the founder of a rising star company in the field of biological antibodies, Luo Peizhi, the founder of Tianyan Pharmaceutical, is quite successful in the field of medical technology. Luo Peizhi graduated from Peking University and received his PhD from the University of Chicago. In 2000, Luo Peizhi founded a biomedical company named Abmaxis, which pioneered a three-dimensional experimental structure that does not rely on antibody antigens. It can design and optimize antibody calculation and screening methods, and provide technical services for the development of innovative drugs for many biological companies around the world. Because of its technological innovation, Abmaxis was acquired by Merck in 2006, and Luo Peizhi himself was hired by Merck as global biopharmaceutical R&D director.</p><p>Around 2011, under the influence of Li Ge, an alumnus and founder of WuXi AppTec, Luo Peizhi decided to return to China to start a business, and soon settled the company in Suzhou, not far from WuXi AppTec's headquarters. In 2014, Tianyan Pharmaceutical completed Series A financing, raising a total of US$8 million. The leading investment institutions include Yaokang Mingde Venture Capital Fund, Fidelity (Boston) Biotechnology Fund, etc. In 2016, WuXi AppTec continued to invest in Tianyan Pharmaceutical's Series B financing, helping Tianyan Pharmaceuticals raise another $28 million. In the following two years, Tianyan Pharmaceutical has successively completed round C and round D financing, with WuXi AppTec behind it.</p><p>Up to now, WuXi AppTec still holds 10.8% of Tianyan Pharmaceutical's shares as a wholly-owned subsidiary Wuxi Pharmaceutical Science and Technology Insurance Fund.</p><p>On the domestic CRO track, WuXi AppTec is undoubtedly the leader. Since 2012, WuXi AppTec has begun to invest in Biotech companies with potential, investing in shares in the early stage to obtain future profits. WuXi AppTec itself has certain clinical trial services and bioanalytical capabilities. In addition to funds, it can also support start-ups with these services. For example, Tianyan Pharmaceutical, in the two years from 2018 to 2020, purchased nearly $15 million in R&D services and quality testing services from WuXi AppTec.</p><p>According to the financial report, in 2018, 2019 and the first nine months ended September 30, 2020, as none of the products were listed, the company's revenue came entirely from the income of licensing patents to the pharmaceutical company Celgene, which was US$1.511 million, US$480,000 and US$310,000 respectively. During the same period, R&D expenditure increased year by year to $16.081 million, $16.212 million and $23.568 million respectively.</p><p>There are no listed drugs that can generate large revenues, and continuous R&D investment also caused Tianyan Pharmaceutical's net losses of US$14.303 million, US$16.678 million, and US$29.815 million in the same period, respectively. The basic and diluted losses per share attributable to common shareholders were $0.94, $1.10, and $1.89, respectively.</p><p>At present, Tianyan Pharmaceutical is also increasing investment in scientific research. The company introduced in the prospectus that Tianyan Pharmaceutical intends to use 95% of the net proceeds from this offering to advance the trial of drug candidates, of which about 26% will be used for the progress of the first and second phase trials of ADG106; 26% of the funds went to ADG126 and ADG116; 43% for the company's technology and platform development and the development of preclinical drug candidates; The remaining approximately 5% is for working capital and other general corporate purposes.</p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/b19a2d6f03716b3591e388e25f762874","relate_stocks":{"ADAG":"天演药业"},"is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1194244001","content_text":"2月9日，临床阶段生物药企天演药业正式在纳斯达克挂牌上市，开盘涨8.95%，报20.7美元，市值8.73亿美元。\n\n天演药业发行价为19美元位于价格指导区间顶端，据悉本次发行735.4万份ADS，市值达到8.01亿美元。高盛、摩根士丹利、Jeffery为联席主承销商，华兴资本为副承销商。\n根据媒体报道，天演药业与CRO巨头药明康德的关系密切，药明康德系天演药业投资方之一，股份占比10.8%。有分析称，天演药业赴美上市，幕后助力者正是药明康德。\n根据官方信息，天演药业成立于2011年，致力于改变基于抗体的新型癌症免疫疗法的发现和开发。成立后的几年间，天演药业自主开发了动态精准抗体技术，建立起全球最大的多样性动态精准抗体库（DPL Platform），以及全球首个融合了精准计算设计与实验构造并集酵母和噬菌体于一体的高通量筛选平台。\n多样性动态精准抗体库是天演药业的核心技术专利。该DPL平台由计算物理技术与AI和大数据相结合提供支持，可对由海量抗体氨基酸序列产生的潜在无限数量的动态结合界面结构进行采样，生产同时具备优异生物学功能与成药性的先到抗体，从而大幅提高抗体药物发现的效率。\n基于这一自有专利平台，天演药物现开发了三个核心产品：ADG106、ADG116和ADG126。其中用于治疗晚期实体瘤、非霍奇金淋巴瘤或NHL的ADG106正在中美两国进行临床试验，已被数据观察到具有良好的抗肿瘤活性与耐受性，最有望实现商业化。\n天演药业的另一产品ADG126，旨在解决与现有批准的CTLA-4免疫肿瘤疗法的MOA相关的毒性和功效问题，并扩大CTLA-4作为癌症治疗靶标的潜力。该产品现已由FDA获批，将于今年在美开展Ⅰ期临床试验。\n作为生物抗体领域的新星企业的创始人，天演药业创始人罗培志在医药科技领域颇为成功。罗培志毕业于北京大学，在美国芝加哥大学获得博士学位。2000年，罗培志创立了一家名为Abmaxis的生物医药公司，开创了不依赖抗体抗原的三维实验结构，可以设计和优化抗体的计算及筛选方法，为全球多家生物公司的创新药开发提供技术服务。因其技术创新，Abmaxis在2006年被默沙东收购，罗培志本人也受聘到默沙东担任全球生物制药研发主任。\n2011年左右，罗培志在校友、药明康德创始人李革的影响下，决定回国创业，很快将公司落户在离与药明康德总部无锡不远的苏州。2014年，天演药业完成A轮融资，共募集资金800万美元。领投机构包括药康明德创投基金、富达（波士顿）生物科技基金等。2016年天演药业的B轮融资，药明康德继续跟投，帮助天演药业再度融资2800万美元。此后的两年中，天演药业陆续完成了C轮、D轮融资，背后都有药明康德的身影。\n截至目前，药明康德仍以全资子公司无锡市医药科技保险基金的身份持有天演药业10.8%的股份。\n在国内CRO赛道上，药明康德无疑是领跑者。从2012年起，药明康德就开始布局投资具有潜力的Biotech公司，前期投资入股，获取未来收益。药明康德本身便具有一定的临床试验服务和生物分析等能力，在资金之外，其也可以凭借这些服务为初创公司提供支持。比如天演药业，在2018年至2020年两年里，共向药明康德购买了近1500万美元的研发服务与质量检测服务。\n财报显示，2018年、2019年及截至2020年9月30日的前9个月，由于产品均未上市，公司收入完全来自向制药公司新基授权专利所得，分别为151.1万美元、48万美元及31万美元。同一时期，研发支出在逐年上升，分别为1608.1万美元、1621.2万美元和2356.8万美元。\n没有能产生大额收入的上市药物，持续不断的研发投入也造成天演药业同期净亏损分别为1430.3万美元、1667.8万美元、2981.5万美元，归属于普通股股东的基本和摊薄每股亏损分别为0.94美元、1.10美元和1.89美元。\n目前，天演药业也在加大科研上的投入。公司在招股书中介绍，天演药业打算利用此次发行的净收益95%用于推进候选药物的试验，其中约26%的资金用于ADG106第一阶段试验和第二阶段试验的进展；26%的资金用于ADG126和ADG116；43%用于公司的技术和平台开发以及临床前候选药物的开发；剩余约5%用于营运资金和其他一般公司用途。","news_type":1,"symbols_score_info":{"ADAG":0.9}},"isVote":1,"tweetType":1,"viewCount":2165,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"EN","totalScore":0},{"id":389552807,"gmtCreate":1612790940909,"gmtModify":1704874223547,"author":{"id":"3565838986169374","authorId":"3565838986169374","name":"手持一堆垃圾","avatar":"https://static.tigerbbs.com/70876ea3d18ea743551d4975c629d41a","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3565838986169374","authorIdStr":"3565838986169374"},"themes":[],"htmlText":".mn","listText":".mn","text":".mn","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/389552807","repostId":"1181758367","repostType":4,"isVote":1,"tweetType":1,"viewCount":2407,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"EN","totalScore":0}],"hots":[{"id":383757819,"gmtCreate":1612898793131,"gmtModify":1704875809110,"author":{"id":"3565838986169374","authorId":"3565838986169374","name":"手持一堆垃圾","avatar":"https://static.tigerbbs.com/70876ea3d18ea743551d4975c629d41a","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3565838986169374","idStr":"3565838986169374"},"themes":[],"htmlText":"m","listText":"m","text":"m","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/383757819","repostId":"1194244001","repostType":4,"repost":{"id":"1194244001","kind":"news","weMediaInfo":{"introduction":"为用户提供金融资讯、行情、数据，旨在帮助投资者理解世界，做投资决策。","home_visible":1,"media_name":"老虎资讯综合","id":"102","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1612889675,"share":"https://ttm.financial/m/news/1194244001?lang=en_US&edition=fundamental","pubTime":"2021-02-10 00:54","market":"us","language":"zh","title":"Tianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%","url":"https://stock-news.laohu8.com/highlight/detail?id=1194244001","media":"老虎资讯综合","summary":"2月9日，临床阶段生物药企天演药业正式在纳斯达克挂牌上市，开盘涨8.95%，报20.7美元，市值8.73亿美元。\n\n天演药业发行价为19美元位于价格指导区间顶端，据悉本次发行735.4万份ADS，市值","content":"<p>On February 9, clinical-stage biopharmaceutical companies<a href=\"https://laohu8.com/S/ADAG\">Tianyan Pharmaceutical</a>Officially listed on Nasdaq, it opened up 8.95% at $20.7, with a market value of $873 million.</p><p><img src=\"https://static.tigerbbs.com/62e01ad7e249639d98c7aa993a51a167\" tg-width=\"1340\" tg-height=\"833\"></p><p>The issue price of Tianyan Pharmaceutical is US$19, which is at the top of the price guidance range. It is reported that 7.354 million ADS were issued this time, with a market value of US$801 million. Goldman Sachs, Morgan Stanley and Jeffery are the co-lead underwriters, and China Renaissance is the deputy underwriter.</p><p>According to media reports, Tianyan Pharmaceutical has a close relationship with CRO giant WuXi AppTec. WuXi AppTec is one of the investors of Tianyan Pharmaceutical, accounting for 10.8% of the shares. According to some analysts, the helper behind Tianyan Pharmaceutical's listing in the United States is WuXi AppTec.</p><p>According to official information, Tianyan Pharmaceuticals was founded in 2011 to transform the discovery and development of novel antibody-based cancer immunotherapies. In the years after its establishment, Tianyan Pharmaceutical independently developed dynamic precision antibody technology, established the world's largest diverse dynamic precision antibody library (DPL Platform), and the world's first high-throughput screening Platform that integrates accurate computational design and experimental structure and integrates yeast and phages.</p><p>Diversity dynamic precision antibody library is the core technology patent of Tianyan Pharmaceutical. The DPL platform is supported by a combination of computational physics technology with AI and big data. It can sample a potentially unlimited number of dynamic binding interface structures generated by massive antibody amino acid sequences, and produce first-come antibodies with both excellent biological functions and drug-ready properties, thus greatly improving the efficiency of antibody drug discovery.</p><p>Based on this own patent platform, Tianyan Pharmaceuticals has now developed three core products: ADG106, ADG116 and ADG126. Among them, ADG106, which is used to treat advanced solid tumors, non-Hodgkin's lymphoma or NHL, is undergoing clinical trials in China and the United States. It has been observed by the data to have good anti-tumor activity and tolerability, and is most expected to be commercialized.</p><p>Another product of Tianyan Pharmaceutical, ADG126, aims to address the toxicity and efficacy issues associated with MOA of existing approved CTLA-4 immuno-oncology therapies and expand the potential of CTLA-4 as a cancer therapeutic target. The product has now been approved by the FDA and will conduct phase I clinical trials in the United States this year.</p><p>As the founder of a rising star company in the field of biological antibodies, Luo Peizhi, the founder of Tianyan Pharmaceutical, is quite successful in the field of medical technology. Luo Peizhi graduated from Peking University and received his PhD from the University of Chicago. In 2000, Luo Peizhi founded a biomedical company named Abmaxis, which pioneered a three-dimensional experimental structure that does not rely on antibody antigens. It can design and optimize antibody calculation and screening methods, and provide technical services for the development of innovative drugs for many biological companies around the world. Because of its technological innovation, Abmaxis was acquired by Merck in 2006, and Luo Peizhi himself was hired by Merck as global biopharmaceutical R&D director.</p><p>Around 2011, under the influence of Li Ge, an alumnus and founder of WuXi AppTec, Luo Peizhi decided to return to China to start a business, and soon settled the company in Suzhou, not far from WuXi AppTec's headquarters. In 2014, Tianyan Pharmaceutical completed Series A financing, raising a total of US$8 million. The leading investment institutions include Yaokang Mingde Venture Capital Fund, Fidelity (Boston) Biotechnology Fund, etc. In 2016, WuXi AppTec continued to invest in Tianyan Pharmaceutical's Series B financing, helping Tianyan Pharmaceuticals raise another $28 million. In the following two years, Tianyan Pharmaceutical has successively completed round C and round D financing, with WuXi AppTec behind it.</p><p>Up to now, WuXi AppTec still holds 10.8% of Tianyan Pharmaceutical's shares as a wholly-owned subsidiary Wuxi Pharmaceutical Science and Technology Insurance Fund.</p><p>On the domestic CRO track, WuXi AppTec is undoubtedly the leader. Since 2012, WuXi AppTec has begun to invest in Biotech companies with potential, investing in shares in the early stage to obtain future profits. WuXi AppTec itself has certain clinical trial services and bioanalytical capabilities. In addition to funds, it can also support start-ups with these services. For example, Tianyan Pharmaceutical, in the two years from 2018 to 2020, purchased nearly $15 million in R&D services and quality testing services from WuXi AppTec.</p><p>According to the financial report, in 2018, 2019 and the first nine months ended September 30, 2020, as none of the products were listed, the company's revenue came entirely from the income of licensing patents to the pharmaceutical company Celgene, which was US$1.511 million, US$480,000 and US$310,000 respectively. During the same period, R&D expenditure increased year by year to $16.081 million, $16.212 million and $23.568 million respectively.</p><p>There are no listed drugs that can generate large revenues, and continuous R&D investment also caused Tianyan Pharmaceutical's net losses of US$14.303 million, US$16.678 million, and US$29.815 million in the same period, respectively. The basic and diluted losses per share attributable to common shareholders were $0.94, $1.10, and $1.89, respectively.</p><p>At present, Tianyan Pharmaceutical is also increasing investment in scientific research. The company introduced in the prospectus that Tianyan Pharmaceutical intends to use 95% of the net proceeds from this offering to advance the trial of drug candidates, of which about 26% will be used for the progress of the first and second phase trials of ADG106; 26% of the funds went to ADG126 and ADG116; 43% for the company's technology and platform development and the development of preclinical drug candidates; The remaining approximately 5% is for working capital and other general corporate purposes.</p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Tianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nTianyan Pharmaceutical listed on Nasdaq today, opening up nearly 9%\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/102\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">老虎资讯综合 </p>\n<p class=\"h-time smaller\">2021-02-10 00:54</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>On February 9, clinical-stage biopharmaceutical companies<a href=\"https://laohu8.com/S/ADAG\">Tianyan Pharmaceutical</a>Officially listed on Nasdaq, it opened up 8.95% at $20.7, with a market value of $873 million.</p><p><img src=\"https://static.tigerbbs.com/62e01ad7e249639d98c7aa993a51a167\" tg-width=\"1340\" tg-height=\"833\"></p><p>The issue price of Tianyan Pharmaceutical is US$19, which is at the top of the price guidance range. It is reported that 7.354 million ADS were issued this time, with a market value of US$801 million. Goldman Sachs, Morgan Stanley and Jeffery are the co-lead underwriters, and China Renaissance is the deputy underwriter.</p><p>According to media reports, Tianyan Pharmaceutical has a close relationship with CRO giant WuXi AppTec. WuXi AppTec is one of the investors of Tianyan Pharmaceutical, accounting for 10.8% of the shares. According to some analysts, the helper behind Tianyan Pharmaceutical's listing in the United States is WuXi AppTec.</p><p>According to official information, Tianyan Pharmaceuticals was founded in 2011 to transform the discovery and development of novel antibody-based cancer immunotherapies. In the years after its establishment, Tianyan Pharmaceutical independently developed dynamic precision antibody technology, established the world's largest diverse dynamic precision antibody library (DPL Platform), and the world's first high-throughput screening Platform that integrates accurate computational design and experimental structure and integrates yeast and phages.</p><p>Diversity dynamic precision antibody library is the core technology patent of Tianyan Pharmaceutical. The DPL platform is supported by a combination of computational physics technology with AI and big data. It can sample a potentially unlimited number of dynamic binding interface structures generated by massive antibody amino acid sequences, and produce first-come antibodies with both excellent biological functions and drug-ready properties, thus greatly improving the efficiency of antibody drug discovery.</p><p>Based on this own patent platform, Tianyan Pharmaceuticals has now developed three core products: ADG106, ADG116 and ADG126. Among them, ADG106, which is used to treat advanced solid tumors, non-Hodgkin's lymphoma or NHL, is undergoing clinical trials in China and the United States. It has been observed by the data to have good anti-tumor activity and tolerability, and is most expected to be commercialized.</p><p>Another product of Tianyan Pharmaceutical, ADG126, aims to address the toxicity and efficacy issues associated with MOA of existing approved CTLA-4 immuno-oncology therapies and expand the potential of CTLA-4 as a cancer therapeutic target. The product has now been approved by the FDA and will conduct phase I clinical trials in the United States this year.</p><p>As the founder of a rising star company in the field of biological antibodies, Luo Peizhi, the founder of Tianyan Pharmaceutical, is quite successful in the field of medical technology. Luo Peizhi graduated from Peking University and received his PhD from the University of Chicago. In 2000, Luo Peizhi founded a biomedical company named Abmaxis, which pioneered a three-dimensional experimental structure that does not rely on antibody antigens. It can design and optimize antibody calculation and screening methods, and provide technical services for the development of innovative drugs for many biological companies around the world. Because of its technological innovation, Abmaxis was acquired by Merck in 2006, and Luo Peizhi himself was hired by Merck as global biopharmaceutical R&D director.</p><p>Around 2011, under the influence of Li Ge, an alumnus and founder of WuXi AppTec, Luo Peizhi decided to return to China to start a business, and soon settled the company in Suzhou, not far from WuXi AppTec's headquarters. In 2014, Tianyan Pharmaceutical completed Series A financing, raising a total of US$8 million. The leading investment institutions include Yaokang Mingde Venture Capital Fund, Fidelity (Boston) Biotechnology Fund, etc. In 2016, WuXi AppTec continued to invest in Tianyan Pharmaceutical's Series B financing, helping Tianyan Pharmaceuticals raise another $28 million. In the following two years, Tianyan Pharmaceutical has successively completed round C and round D financing, with WuXi AppTec behind it.</p><p>Up to now, WuXi AppTec still holds 10.8% of Tianyan Pharmaceutical's shares as a wholly-owned subsidiary Wuxi Pharmaceutical Science and Technology Insurance Fund.</p><p>On the domestic CRO track, WuXi AppTec is undoubtedly the leader. Since 2012, WuXi AppTec has begun to invest in Biotech companies with potential, investing in shares in the early stage to obtain future profits. WuXi AppTec itself has certain clinical trial services and bioanalytical capabilities. In addition to funds, it can also support start-ups with these services. For example, Tianyan Pharmaceutical, in the two years from 2018 to 2020, purchased nearly $15 million in R&D services and quality testing services from WuXi AppTec.</p><p>According to the financial report, in 2018, 2019 and the first nine months ended September 30, 2020, as none of the products were listed, the company's revenue came entirely from the income of licensing patents to the pharmaceutical company Celgene, which was US$1.511 million, US$480,000 and US$310,000 respectively. During the same period, R&D expenditure increased year by year to $16.081 million, $16.212 million and $23.568 million respectively.</p><p>There are no listed drugs that can generate large revenues, and continuous R&D investment also caused Tianyan Pharmaceutical's net losses of US$14.303 million, US$16.678 million, and US$29.815 million in the same period, respectively. The basic and diluted losses per share attributable to common shareholders were $0.94, $1.10, and $1.89, respectively.</p><p>At present, Tianyan Pharmaceutical is also increasing investment in scientific research. The company introduced in the prospectus that Tianyan Pharmaceutical intends to use 95% of the net proceeds from this offering to advance the trial of drug candidates, of which about 26% will be used for the progress of the first and second phase trials of ADG106; 26% of the funds went to ADG126 and ADG116; 43% for the company's technology and platform development and the development of preclinical drug candidates; The remaining approximately 5% is for working capital and other general corporate purposes.</p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/b19a2d6f03716b3591e388e25f762874","relate_stocks":{"ADAG":"天演药业"},"is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1194244001","content_text":"2月9日，临床阶段生物药企天演药业正式在纳斯达克挂牌上市，开盘涨8.95%，报20.7美元，市值8.73亿美元。\n\n天演药业发行价为19美元位于价格指导区间顶端，据悉本次发行735.4万份ADS，市值达到8.01亿美元。高盛、摩根士丹利、Jeffery为联席主承销商，华兴资本为副承销商。\n根据媒体报道，天演药业与CRO巨头药明康德的关系密切，药明康德系天演药业投资方之一，股份占比10.8%。有分析称，天演药业赴美上市，幕后助力者正是药明康德。\n根据官方信息，天演药业成立于2011年，致力于改变基于抗体的新型癌症免疫疗法的发现和开发。成立后的几年间，天演药业自主开发了动态精准抗体技术，建立起全球最大的多样性动态精准抗体库（DPL Platform），以及全球首个融合了精准计算设计与实验构造并集酵母和噬菌体于一体的高通量筛选平台。\n多样性动态精准抗体库是天演药业的核心技术专利。该DPL平台由计算物理技术与AI和大数据相结合提供支持，可对由海量抗体氨基酸序列产生的潜在无限数量的动态结合界面结构进行采样，生产同时具备优异生物学功能与成药性的先到抗体，从而大幅提高抗体药物发现的效率。\n基于这一自有专利平台，天演药物现开发了三个核心产品：ADG106、ADG116和ADG126。其中用于治疗晚期实体瘤、非霍奇金淋巴瘤或NHL的ADG106正在中美两国进行临床试验，已被数据观察到具有良好的抗肿瘤活性与耐受性，最有望实现商业化。\n天演药业的另一产品ADG126，旨在解决与现有批准的CTLA-4免疫肿瘤疗法的MOA相关的毒性和功效问题，并扩大CTLA-4作为癌症治疗靶标的潜力。该产品现已由FDA获批，将于今年在美开展Ⅰ期临床试验。\n作为生物抗体领域的新星企业的创始人，天演药业创始人罗培志在医药科技领域颇为成功。罗培志毕业于北京大学，在美国芝加哥大学获得博士学位。2000年，罗培志创立了一家名为Abmaxis的生物医药公司，开创了不依赖抗体抗原的三维实验结构，可以设计和优化抗体的计算及筛选方法，为全球多家生物公司的创新药开发提供技术服务。因其技术创新，Abmaxis在2006年被默沙东收购，罗培志本人也受聘到默沙东担任全球生物制药研发主任。\n2011年左右，罗培志在校友、药明康德创始人李革的影响下，决定回国创业，很快将公司落户在离与药明康德总部无锡不远的苏州。2014年，天演药业完成A轮融资，共募集资金800万美元。领投机构包括药康明德创投基金、富达（波士顿）生物科技基金等。2016年天演药业的B轮融资，药明康德继续跟投，帮助天演药业再度融资2800万美元。此后的两年中，天演药业陆续完成了C轮、D轮融资，背后都有药明康德的身影。\n截至目前，药明康德仍以全资子公司无锡市医药科技保险基金的身份持有天演药业10.8%的股份。\n在国内CRO赛道上，药明康德无疑是领跑者。从2012年起，药明康德就开始布局投资具有潜力的Biotech公司，前期投资入股，获取未来收益。药明康德本身便具有一定的临床试验服务和生物分析等能力，在资金之外，其也可以凭借这些服务为初创公司提供支持。比如天演药业，在2018年至2020年两年里，共向药明康德购买了近1500万美元的研发服务与质量检测服务。\n财报显示，2018年、2019年及截至2020年9月30日的前9个月，由于产品均未上市，公司收入完全来自向制药公司新基授权专利所得，分别为151.1万美元、48万美元及31万美元。同一时期，研发支出在逐年上升，分别为1608.1万美元、1621.2万美元和2356.8万美元。\n没有能产生大额收入的上市药物，持续不断的研发投入也造成天演药业同期净亏损分别为1430.3万美元、1667.8万美元、2981.5万美元，归属于普通股股东的基本和摊薄每股亏损分别为0.94美元、1.10美元和1.89美元。\n目前，天演药业也在加大科研上的投入。公司在招股书中介绍，天演药业打算利用此次发行的净收益95%用于推进候选药物的试验，其中约26%的资金用于ADG106第一阶段试验和第二阶段试验的进展；26%的资金用于ADG126和ADG116；43%用于公司的技术和平台开发以及临床前候选药物的开发；剩余约5%用于营运资金和其他一般公司用途。","news_type":1,"symbols_score_info":{"ADAG":0.9}},"isVote":1,"tweetType":1,"viewCount":2165,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"EN","totalScore":0},{"id":389552807,"gmtCreate":1612790940909,"gmtModify":1704874223547,"author":{"id":"3565838986169374","authorId":"3565838986169374","name":"手持一堆垃圾","avatar":"https://static.tigerbbs.com/70876ea3d18ea743551d4975c629d41a","crmLevel":11,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3565838986169374","idStr":"3565838986169374"},"themes":[],"htmlText":".mn","listText":".mn","text":".mn","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://ttm.financial/post/389552807","repostId":"1181758367","repostType":4,"repost":{"id":"1181758367","kind":"news","weMediaInfo":{"introduction":"为用户提供金融资讯、行情、数据，旨在帮助投资者理解世界，做投资决策。","home_visible":1,"media_name":"老虎资讯综合","id":"102","head_image":"https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba"},"pubTimestamp":1612790230,"share":"https://ttm.financial/m/news/1181758367?lang=en_US&edition=fundamental","pubTime":"2021-02-08 21:17","market":"us","language":"zh","title":"Bitcoin rises to the 8th worldwide market cap asset, surpassing Facebook","url":"https://stock-news.laohu8.com/highlight/detail?id=1181758367","media":"老虎资讯综合","summary":"2月8日，AssetDash数据显示，目前比特币市值超过7900亿美元，与知名公司股票市值相比，排名升至第8位，超越脸书（市值现报7651.57亿美元），排在特斯拉之后（市值现报8078.29亿美元）","content":"<p>On February 8th, AssetDash data showed that the current market value of Bitcoin exceeds 790 billion US dollars, ranking 8th compared with the stock market value of well-known companies, surpassing Facebook (the market value is now reported at 765.157 billion US dollars) and ranking<a href=\"https://laohu8.com/S/TSLA\">Tesla</a>After (the market cap is now traded at $807.829 billion).</p>","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; 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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 12.5px; color: #7E829C; margin: 0;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nBitcoin rises to the 8th worldwide market cap asset, surpassing Facebook\n</h2>\n<h4 class=\"meta\">\n<a class=\"head\" href=\"https://laohu8.com/wemedia/102\">\n\n<div class=\"h-thumb\" style=\"background-image:url(https://static.tigerbbs.com/8274c5b9d4c2852bfb1c4d6ce16c68ba);background-size:cover;\"></div>\n\n<div class=\"h-content\">\n<p class=\"h-name\">老虎资讯综合 </p>\n<p class=\"h-time smaller\">2021-02-08 21:17</p>\n</div>\n</a>\n</h4>\n</header>\n<article>\n<p>On February 8th, AssetDash data showed that the current market value of Bitcoin exceeds 790 billion US dollars, ranking 8th compared with the stock market value of well-known companies, surpassing Facebook (the market value is now reported at 765.157 billion US dollars) and ranking<a href=\"https://laohu8.com/S/TSLA\">Tesla</a>After (the market cap is now traded at $807.829 billion).</p>\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/e8e7a6266784418dec934d26eb8ce628","relate_stocks":{},"is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1181758367","content_text":"2月8日，AssetDash数据显示，目前比特币市值超过7900亿美元，与知名公司股票市值相比，排名升至第8位，超越脸书（市值现报7651.57亿美元），排在特斯拉之后（市值现报8078.29亿美元）。","news_type":1,"symbols_score_info":{}},"isVote":1,"tweetType":1,"viewCount":2407,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"EN","totalScore":0}],"lives":[]}
